In obese people, some hormones secreted from fat cells reduce the effect of insulin on cells, and disruptions occur in the transfer of sugar from the blood to the cells. As a result, the concentration of sugar in the blood increases. This condition is called insulin resistance. People who develop this insulin resistance need much more insulin than the insulin normally needed for sugar regulation.
Insulin resistance is the most important factor in the formation of type 2 diabetes. In normal people, the insulin released to lower blood sugar is very insufficient to lower blood sugar in the presence of this resistance and cannot regulate blood sugar. The pancreas then secretes more insulin.
Obese patients with insulin resistance or type 2 diabetes often secrete much more insulin, and blood insulin levels are generally high. As obesity increases, insulin resistance increases and as insulin resistance increases, the required amount of insulin increases. Up to a certain point, the pancreas overworks and compensates for this situation. To correct diabetes above a certain stage, external antidiabetic drugs or insulin support are required.
High levels of insulin in the body stimulate the hunger center, causing him to eat more and worsen his obesity. That’s why these fat type 2 diabetics are stuck in a vicious circle that’s hard to break. It is very difficult for these patients to comply with their diets, and to control weight and sugar levels, and it requires a lot of hard work.
In obese patients with type 2 diabetes, especially if sugar cannot be controlled despite drug therapy, an appropriate metabolic surgery option can be offered to the patient after a very good evaluation.