Assoc. Dr. Nadiye Köroğlu made important statements about frozen embryo transfer, which is more preferred in IVF treatment. Assoc. Dr. Köroğlu stated that in frozen embryo transfer, frozen good quality embryos obtained from the previous IVF treatment were thawed and transferred to the uterus of the expectant mother, “Frozen embryo transfer has started to be applied more frequently as an alternative to fresh embryo transfer.

Recent studies have revealed that hormone drugs used to grow eggs can adversely affect the uterine wall and reduce the adhesion strength of the embryo to the uterus. In order to eliminate this negative effect, the drug effect is expected to disappear and the uterus to return to its natural state. With this method, pregnancy rates of 5 to 10 percent are obtained compared to freshly transferred patients, ”he said.


Assoc. Dr. Köroğlu listed the situations in which frozen embryo transfer is applied as follows:

“It is applied when pregnancy cannot be achieved with fresh transfer, and when it is desired to have a child after a miscarriage or birth. In addition, this method is used to avoid the risk of overstimulation syndrome in patients with polycystic ovary syndrome or more than 15 eggs collected. It is also preferred if polyps are detected in the uterus during the IVF process, or if the uterine wall is not thick enough or there is bleeding during the treatment process. It is applied after the diagnosis of cancer, the embryo is frozen before chemotherapy and radiotherapy, and after the treatment is completed and recovery is achieved. In in vitro fertilization with genetic diagnosis, embryos are frozen until the biopsy results obtained from the embryos, and this method is used in the transfer of genetically normal embryos. “


The advantages of frozen embryo transfer compared to fresh transfer Assoc. Dr. Köroğlu explained:

“The expectant mother is prepared for embryo transfer without using hormone injections and egg collection. Since these transactions are not carried out, it is more suitable financially. In this process, the stress of expectant mothers is less, as the use of medication and the number of visits to the hospital is less. Somewhat higher pregnancy rates are obtained in frozen embryo transfer. In frozen embryo transfer, before the embryo thaw, the uterine wall must be prepared so that the embryo can adhere. “


Assoc. Dr. Drawing attention to the fact that frozen embryo transfer can be done in two ways, Köroğlu said, “First, it can be done with hormone drugs. It is especially preferred for women with irregular periods. Estrogen medication is started on the 2nd or 3rd day of the period. After 10 to 14 days of drug use, the thickness of the uterine wall is evaluated with ultrasound. If the uterine wall is of sufficient thickness, progesterone hormone is added and the embryo transfer day is adjusted according to the day of the frozen embryo. For example, for embryos frozen on the 5th day, embryo transfer is planned on the 6th day after progesterone is started.

Since there is no hormone production from the ovaries, these drugs should be continued until the 10th to 12th week of pregnancy in case pregnancy occurs. Secondly, it can be done with the natural cycle. No medication is used to suppress ovulation in frozen embryo transfer with natural cycle. Instead, the day of embryo transfer is determined by the time of ovulation. For this reason, it can be applied to women with regular menstruation. The uterine wall and ovaries are checked with ultrasound on the 2nd or 3rd day of menstruation. A second control is planned according to the cycle length of the expectant mother. In this control, whether there is egg development and egg size is checked. Since it is important to determine the exact day of ovulation, ultrasound and blood tests are performed at regular intervals. “The embryo transfer day is determined according to the time of ovulation.”


Assoc. Dr. Köroğlu continued his statements as follows:

“On the embryo transfer day, frozen embryos are removed from liquid nitrogen, thawed at room temperature and placed in the device in a special culture medium. Embryo transfer is performed under ultrasound control when the woman is urinating. By entering into the uterus with the help of a catheter, the embryos are left in a suitable area without touching the uterine wall. Although there is no information that resting the patient after this procedure increases the pregnancy rate, he is sent home after a short period of follow-up in the clinic. Frozen embryo transfer applications are safe and very economical applications for the patient. “

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