Saying that quercetin, which belongs to a group of plant pigments called flavonoids that give color to many fruits, flowers and vegetables, is one of the most abundant antioxidants in the diet, Associate Professor of Infectious Diseases and Clinical Microbiology. Dr. Ümit Savaşçı stated that it plays an important role in helping the body fight free radical damage associated with chronic diseases. Assoc. Dr. The war also informed about the medicinal uses of quercetin.
Assoc. Dr. “Today, medical use of quercetin is combined with its antioxidant, anti-inflammatory, antiplatelet, antiapoptotic, nephro, gastro, angio, cardio and chondroprotective properties. The last point reached in its use for medical purposes has been the investigation of its effectiveness in the treatment of the coronavirus pandemic, which is the deadliest disease of our age and affects our country and the whole world.
Hundreds of experimental researches have been conducted in many countries on this subject, and scientists have published them in the form of articles and reviews to serve humanity. Biancatelli et al. Presented current evidence of the use of vitamin C and quercetin as an adjunct to pharmacological agents such as Remdesivir or convalescent plasma, an antiviral drug that is effectively used both in prophylaxis in high-risk populations and in the treatment of Kovid-19. “They emphasized that a safe biological molecule like Quercetin is the biological molecule that should be prioritized for use in the global health pandemic.”
Assoc. Dr. The war continued his words as follows:
“Abian and colleagues screened a drug library of 150 chemical compounds and identified the natural product quercetin as a reasonably potent inhibitor of 3CLpro (the main protease enzyme highly protected among coronaviruses), an enzyme of the SARS-CoV-2 virus. They stated that quercetin can be considered as a good candidate with optimization and development for the therapeutic treatment of Kovid-19. Liu et al. Angiotensin converting enzyme-2 (ACE 2) is the human cell entry receptor in COVID-19 disease.
As is known, this protein is the protein to which the virus targeted by most of the existing vaccines binds with the S protein, that is, the most critical step in the initiation of infection and virus transmission. In this experimental study, it was aimed to determine whether various polyphenols inhibit recombinant human ACE-2 activity. Quercetin was found to be the strongest ACE-2 inhibitor among the polyphenols tested, and has been shown to inhibit ACE-2 activity at physiological concentrations. In Derosa’s review article, he highlighted the results showing that quercetin stopped the replication of the SARS ‐ CoV ‐ 2 virus, making it the fifth best compound among 18 candidates. “
Within the scope of the studies, it was emphasized that on the basis of clinical symptoms of Kovid-19, it was emphasized that quercetin should be taken into consideration both its anti-inflammatory and thrombin inhibitor effects as well as its multifaceted therapeutic power as preventing clot formation. Dr. Savaş said, “The most important study on this subject in our country is Professor of Health Sciences University at Kanuni Sultan Süleyman Training and Research Hospital. Dr. It was made by Hasan Önal. 113 healthcare professionals were included in this study. Two different comparative groups have been created.
The first group formed by giving 2 divided doses of 500 mg of quercetin and 500 mg of vitamin C (QC) to 71 healthcare workers working in areas with high risk of Kovid-19 disease was determined as the protection group, and 42 people who did not receive this treatment were determined as the control group. Study groups were followed for 118 days, and only 1 health worker in the quercetin and vitamin C group and 9 out of 42 people in the control group developed Kovid-19 disease during the follow-up period.
Even if we are in high-risk environments for Kovid-19, it has been proven in many scientific studies that the quercetin and vitamin C complex, which protect us, prevent coronaviruses from binding to ACE receptors and entering the human cell. Thus, it prevents the transmission of the disease directly. It has also been shown that this valuable antioxidant, which has a place in treatment, also prevents the replication of the virus in the body. In this way, it also contributes greatly to the treatment of coronavirus and facilitates and accelerates the recovery by alleviating the symptoms, namely the symptoms of the disease ”.
Assoc. Dr. Savaş said, “A reputable medical school in Virginia Eastern Virginia Medical School (EVMS) recommends quercetin and vitamin C treatment complex in the Kovid-19 management protocol in the prevention of disease, that is, prophylaxis, and more importantly, for treatment at home and in the hospital in mild cases of Kovid-19. In addition, the FLCCC Alliance was created in March 2020 by a group of highly renowned academics, with academic support from doctors from all over the world, to investigate protocols for the prevention and treatment of COVID-19 in all disease stages. They published many treatment protocols and guidelines. In the guide of this important institution, quercetin and vitamin C treatment complex are recommended for prophylaxis and treatment of outpatient covid-19 cases, ”he said.
Assoc. Dr. Ümit Savaş concluded his words as follows:
“As a result, I think quercetin, which is a natural molecule, can be used safely in order not to get covid 19 disease, in outpatient treatment even if it is caught, and again very importantly, even if it is the most important protective weapon such as vaccine, in vaccinees against the possibility of mutated viruses to escape from the vaccine. I am currently using quercetin and vitamin C complex as a healthcare worker who has always voluntarily made the MRNA vaccine working in the field in the fight against Kovid-19. “