Prof. from the Department of Organ Transplantation. Dr. Stating that Kovid-19 affects many organs other than the lungs, Onur Yaprak made important statements. prof. Dr. Stating that the pandemic process has been going on for about 1.5 years, Yaprak said, “We now have much more information than we knew at the beginning of the epidemic about the Kovid-19 infection, which was declared a pandemic by the World Health Organization on March 11, 2020.
We have left behind a period of close to 1.5 years in the epidemic by learning something new every day, and during this time thousands of scientific articles have been published about the disease.
Drawing attention to the results of the publications that have emerged after at least 6 months of people who have had the disease during the past period, Prof. Dr. Leaf said:
“First of all, Sars-Cov-2 virus causes a systemic disease that is initially transmitted by droplet infection but then affects all organs in the body. The underlying reason for this is the presence of ACE receptors in nearly 20 organs and tissues, where the virus enters the body, the virus’s intense involvement of the vessels, and the fact that all organs contain vessels.
Secondly, the sequelae of the organs, which are called prolonged Kovid and retained in some of those who survived the disease, lead to complaints that lasted for months. The persistence of some complaints that last longer than 3-4 weeks after the disease is called prolonged covid. If this situation lasts for more than 3 months, it is called chronic Kovid, and it is more common in those who have a severe disease and recover.”
prof. Dr. Stating that the virus does not only harm the lungs, Yaprak said, “The liver, heart, kidney, intestine, brain, nervous system and even our skin can be affected by the coronavirus at varying rates. Since ACE receptors are very intense in the liver and intestines, the most affected organ after the lung is the digestive system.
In 20 to 30 percent of patients, symptoms such as 2 to 5 times elevation in liver enzymes, nausea, vomiting, and abdominal pain develop. Possible mechanisms underlying the effect of the liver, the virus causing coagulation in the capillaries in the organs, the deterioration of the blood supply to the organs, the overreaction of the immune system, the changes in intra-abdominal pressure due to being connected to the respirator in the intensive care unit, the side effects of the drugs, the entry of toxins into the liver through the systemic circulation due to the deterioration of the permeability of the intestine, They are causes such as pause in bile production and secretion, exacerbation of underlying liver disease.
prof. Dr. Onur Yaprak said, “In autopsy studies performed on patients who died due to Kovid, virus fragments in the electron microscope in the liver, PCR positivity in the liver tissue, inflammation and fat were detected. Patients with liver involvement have a more severe disease and a 3-fold increase in death rates. In healed patients, liver enzymes usually return to normal if there is no underlying liver disease, but causes the disease to progress in those with underlying liver disease.
In some patients, complaints such as nausea and abdominal pain may continue for weeks. Complaints of fatigue, weakness, and fatigue last for weeks, sometimes months, in an average of half of those with severe disease. In 1/3 of the patients with mild to moderate sequelae in the lungs, shortness of breath continues for months due to the loss of elasticity in the lung, which we call fibrosis, and the deterioration in the oxygenation of the blood. This picture is even more severe in those who have more severe disease. It was reported that 2.5 percent of the recovered patients developed intravascular coagulation problems 1 month after discharge.
Referring to the effect of coronavirus on the heart and nervous system, Prof. Dr. Leaf continued:
“In terms of the heart, the virus causes inflammation in the heart muscle. Over time, the development of lubrication and fibrosis in the heart muscle can lead to problems such as heart failure, rhythm disorders, and chest pain. At 6-month follow-up, palpitations were reported in 9 percent of the patients, and chest pain persisted in 5 percent. In autopsy studies performed on patients who died in the epidemic, the virus was found in the heart tissue of 62.5% of the patients in electron microscopy.
In terms of the nervous system, 10 to 30 percent of patients who are seen during the disease process develop complaints such as depression, headache, muscle pain, loss of taste and smell, and some of these complaints last for weeks or months. In terms of kidneys, acute kidney injury develops in 5 percent of all hospitalized patients and 30 percent of patients hospitalized in the intensive care unit, and at the end of 6 months, 13 percent of the recovered patients have decreased kidney functions. The disease can cause some problems even in the skin, and hair loss was observed in 15 to 20 percent of the patients.