Endocrinology and Metabolic Diseases Specialist Dr. Safiye Arık said, “The desk-top working style has increased significantly, with the changes in the diet, obesity and consequently insulin resistance gradually increases in this group of people. At the outset, I would like to emphasize that insulin resistance does not cause overweight or weight gain, on the contrary, being overweight or gaining weight causes insulin resistance. In other words, because we are overweight, we have insulin resistance, if we lose weight and return to our normal weight, insulin resistance will improve, ”he said.


Saying that insulin is a naturally occurring hormone in our bodies, simply expressed in the pancreas, it is a hormone that lowers blood sugar. Dr. Safiye Arık, “Diabetes occurs in the decrease and deficiency of its effect. Insulin resistance is the reduction in the degree of low blood sugar that occurs with insulin, meaning more insulin is required to adequately lower blood sugar. The most common cause of insulin resistance is obesity.

The consequences of obesity-related insulin resistance are as follows; high fasting sugar (without diabetes), high 2nd hour sugar in sugar loading test (without diabetes), diabetes (type 2), high blood fat (triglyceride), low benign cholesterol (HDL), high blood pressure, sugar pill or increased sugar levels in people using insulin, cardiovascular disease, polycystic ovary syndrome, non-alcoholic fatty liver disease, some cancers (such as breast, colon, uterine cancer). Obesity, especially abdominal obesity, is closely related to insulin resistance. Initially, our pancreas increases the amount of insulin secreted, compensating and correcting this situation, that is, insulin resistance. Blood sugars are normal or slightly elevated in many patients with obesity-related insulin resistance. However, many patients cannot maintain this correction, this compensation, and eventually become diabetic (type 2). “In large population-based studies, a formula called HOMA-IR, calculated with fasting glucose and insulin levels, was used for the diagnosis of insulin resistance.”


Dr. Safiye Arık said, “The basis of the treatment is weight loss and increasing physical activity. In addition, Metformin active ingredient drugs are effective in preventing the development of diabetes, but are not as effective as diet and exercise. That’s why the main treatment is weight loss and exercise. The Mediterranean diet has proven to be effective and sustainable in this group of patients. Dietary activities should be supported with personalized exercise programs. Moderate cardio group aerobic exercises have proven effective in this regard. Exercises that can increase the heart rate at a certain level such as brisk walking, low tempo jogging, swimming, and cycling can be recommended. However, high blood pressure and high cholesterol should also be treated in order to reduce the risk of cardiovascular diseases. Metformin and pioglitazone can be used in high-risk patients to correct insulin resistance and reduce the development of diabetes ”.


Explaining the symptoms of insulin resistance, Dr. Safiye Arık said, “In the body where insulin resistance develops, the cells cannot take and use the glucose in the blood normally. Our body increases the amount of insulin secreted from the pancreas in order to overcome this situation. In other words, more than normal amount of insulin is secreted into our blood. Excessively increased insulin accelerates the entry of glucose in the blood into the cells, even if our blood sugar is consumed fast even if our blood sugar is not below normal levels, fatigue after meals, the need to consume sugary food and especially after a few hours after meals, excessive hunger, irritability, numbness, palpitations, headache, hand and foot tremors. it may show symptoms, ”he said.


Stating that almost everyone is exposed to stress from time to time, Dr. Safiye Arık said, “However, stress hormones adrenaline and cortisol are secreted more in people who are under constant stress. These hormones also facilitate insulin resistance. Not choosing pastries and high-calorie foods for breakfast; If possible, consuming breakfast foods such as cheese, olives, tomatoes, cucumbers, Preparing a healthy meal instead of ordering lunch from outside, preferring a healthy meal, Choosing light desserts to minimize the consumption of desserts, Limiting the consumption of tea and coffee, “We should not prefer alcohol or soft drinks, drink 1.5-2lt of water a day, be as active as possible during work, practice simple exercises during the day.”

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