Drawing attention to the fact that jaundice may be a symptom of an important disease, Prof. Dr. Onur Yaprak refers to the yellowing of the eyes, skin and mucous membranes due to the increase in bile pigment, namely bilirubin, in the blood. The total bilirubin level in the blood test is normally 0.3-1.2 mg / dl, and if this value reaches 2.5-3.0 mg / dl, jaundice occurs. Jaundice is a symptom of an ailment, not a disease itself. The reasons leading to jaundice are very diverse, ”he said.
Listing the underlying causes of jaundice, Prof. Dr. Yaprak said, “Many diseases, from harmless genetic inherited conditions in which the uptake or excretion of bilirubin into the liver is impaired, hematological diseases caused by hemolysis, ie blood red blood cells, or liver diseases, bile duct and pancreatic cancers, can cause jaundice.
Among all these reasons, undoubtedly, the most feared conditions are cancers that develop in the liver, pancreas, gall bladder and biliary tract. Cancers that develop in these regions cause a blockage in the flow of bile produced in the liver to the duodenum, and the excessive mixing of the bilirubin substance in the blood causes yellowness in the eyes and skin, darkening in the urine, and the color of the stool.
Stating that cancers that develop in the bile ducts inside the liver and outside the liver are called cholangiocancer. Dr. “While 90 percent of cholangiocancers develop in the bile ducts other than the liver, only 10 percent develop inside the liver. Half of the cholangiocancers that develop outside the liver are located at the point where the bile duct comes out of the liver immediately and is called ‘clastkin tumor’.
Cholangiocancers constitute 3 percent of cancers in the digestive system. It is seen in 1 person in every 10 thousand to 100 thousand in terms of incidence. The prevalence rate of pancreatic cancers in the society is 5 to 12 per 100 thousand people. While pancreatic cancers are in the 11th place in terms of cancer frequency, it is the 4th in the USA and the 7th in the world in cancer-related deaths. According to the data of the American Cancer Society, pancreatic cancers account for 3 percent of all cancers and 7 percent of cancer-related deaths, ”he said.
Mentioning that among the risk factors for cholangiocancers, chronic inflammation affecting the bile ducts for a long time is responsible. Dr. Leaf made the following assessment:
“Most of these patients are over 50 years old. Cyst and stone formation in the bile ducts, presence of parasites, smoking, hepatitis B and C, genetic factors, prolonged exposure to chemicals, obesity and diabetes are the main risk factors. Among the risk factors that predispose to pancreatic cancer; Smoking and alcohol use, advanced age, diabetes, chronic pancreatitis, a fast food diet rich in fatty meat cooked at high temperatures, processed meats containing nitrite, genetic and familial predisposition.
Genetic and familial factors have an impact of 10 percent. The most feared aspect of cancers developing in the liver, bile ducts and pancreas is that the vital vessels of most patients are affected by cancer at the time of diagnosis and many patients have lost the chance of surgery. Unfortunately, only 20 percent of patients in this region can have a chance of surgery. Therefore, early diagnosis before vascular involvement occurs is the most important issue. “