exp. Dr. Gülnara Haydarova said, “Fever can become periodic, especially in some cases. Periodic fever syndrome should be considered in children who experience fever attacks 11-12 times a year and whose attacks recur every 28 days. The diagnosis of periodic fever syndrome can be easily made in routine child examinations.


Stating that children can have an average of 9 upper respiratory tract infections per year and the majority of them are of viral origin, Haydarova said, “In addition, periodic fever syndromes should be considered in children with frequent febrile illness, especially if the fever is cyclical. PFAPA syndrome, which is one of the most common syndromes with periodic fever in children; that is, it is defined as periodic fever, aphthous stomatitis, pharyngitis and adenitis.

exp. Dr. Haydarova continued her words as follows:

“PFAPA is a disease with recurrent fever, aphthous mouth sores, pharyngitis (inflammation of the throat), and neck glands. The disease mostly occurs under the age of five. PFAPA has a chronic course, but gets better with time. There is no definitive laboratory diagnosis. The diagnosis is made by the patient’s clinical findings and laboratory tests. These laboratory tests measure the increased erythrocyte sedimentation rate (ESH) and blood C-reactive protein (CRP) levels during attacks. The diagnosis is made by a pediatrician by taking the patient’s history and by detailed examination. The cause of the disease is unknown. Although rare familial cases have been reported, no genetic cause has been found.”


Stating that the fever attacks start suddenly and usually pass spontaneously within 3-6 days, Dr. Dr. Gulnara Haydarova, Fever attacks usually recur regularly every few weeks. Fever is usually above 39 degrees Celsius in children and is unresponsive to all antibiotics and antipyretic treatments.

Haydarova listed the main symptoms of PFAPA as follows:

“Fever, sore throat, mouth sores, swollen lymph nodes in the neck.”

Stating that additional symptoms such as weakness, joint pain, abdominal pain, headache, vomiting or diarrhea can be seen in children, Dr. Dr. Haydarova said, “There is no disease-specific treatment that completely cures PFAPA syndrome. The goal of treatment is to control symptoms during fever attacks. The response of fever attack to steroid treatment is accepted as a diagnostic criterion. At least 3 fever attacks in the throat (less than 7 days, regular and periodic), pharyngitis and painful throat swelling or aphthous ulcer in the mouth, the presence of a child with normal growth and development, appearing healthy between the fever attacks, and symptoms as a result of a single dose of steroid treatment. PFAPA should be considered in the presence of conditions such as recovery,” he said.

Leave a Reply

Your email address will not be published. Required fields are marked *