Cardiovascular Surgery Specialist Prof. Dr. Barış Durukan, in his written statement, stated that ‘broken heart syndrome’, whose scientific name is ‘Takatsubo cardiomyopathy’, is a temporary heart failure condition. prof. Dr. Durukan said, “Typically, it progresses with ballooning at the end of the heart. Patients present with palpitations, shortness of breath and swelling in the body. Quick fatigue and decreased effort capacity are other accompanying findings. It usually develops following emotional distress, natural disasters and the death of a loved one. It is called “Broken Heart Syndrome. It is more common in postmenopausal women in their 60s. It completely resolves with the disappearance of emotional distress.”


prof. Dr. Durukan stated that Takotsubo cardiomyopathy (TCM), also known as ‘broken heart syndrome’, is a temporary heart syndrome involving left ventricular apical akinesia, “It mimics acute coronary syndrome. Its name is derived from the Japanese word ‘takotsubo’; it is used by Japanese fishermen to catch octopus. The device has a rounded bottom and a narrow neck, and is similar to the apical left ventricular ballooning that develops in disease. TCM is usually seen in postmenopausal women aged 65 to 70. In contrast, studies in Asia have shown a higher incidence in men. , varies from 13 percent to 35 percent. The disease is reversible. It progresses with transient systolic and diastolic left ventricular dysfunction and reversible wall motion abnormalities. It often develops following emotional distress, natural disasters, and death of a loved one. It has been described in the pathophysiology of the brain-heart axis and there is an excess of catecholamines He used his fades.

Stating that the disease is also described in mythology, Durukan said, “Stratonikeia, known as the ancient city of eternal love and gladiators, is located in Yatağan, Muğla, on the border of Eskihisar Village. Stratonikeia, one of the most important city-states of Caria, has been inhabited since the late Bronze Age until today. The Byzantine Stephenus inscriptions tell us: ‘a fascinating tale of hopeless love and disappointment.’ Antiochus I Soter, the son of King Seleukos I, the 1st King of Caria, fell in love with his father’s beautiful wife Stratonikeia. However, he suffered greatly because of this forbidden love and Antiochus fell ill. The king invited doctors from all over the country to find out what happened. Unfortunately All attempts to understand the cause of the cruel disease failed. As Antiochus’ condition worsened day by day, the King was suffering for his son’s condition and summoned the famous doctor named Erasistratus from Ceos (Kos). He is known as the first cardiologist mentioned, as he was the first to describe the rhythm and the vessels feeding the heart. Erasistratus observed Antiochus for days.When Stratonikeia visited Antiochus’ room, Antiochus’ condition worsened and his pulse increased, shortness of breath, chest pain and facial symptoms were noted. Erasistratus diagnosed Antiochus’ condition as hopeless love and sought treatment for the King. He said that there was only one solution and saved him from a serious stalemate. The king had to renounce his wife and allowed his son to marry Stratonikeia. Eventually, Nicator abdicated and Antiochus married Stratonikeia. Fully recovered, he built a city dedicated to him. He lived in Stratonikeia until the end of his life and died at the age of sixty.”


prof. Dr. Durukan stated that the old mythological story reminds of ‘broken heart syndrome’ and said:

“Antiochus’ symptoms were due to the discharge of catecholamines associated with the longing accompanying Stratonikeia’s unrequited love. There are other possible explanations for the symptoms, such as anxiety and related psychiatric disorders. However, the symptoms described and the history were judged to be TCM, in our opinion, resulting from emotional distress. The symptoms experienced by the Prince it started with falling in love, she was disappointed and emotionally distressed. The symptoms were particularly tachycardia and dyspnea compatible with heart failure, also decreased effort capacity. Points that can distinguish the diagnosis from psychiatric disorders are the aggravation of the symptoms when she sees Stratonikeia, which is the cause of emotional stress. Another clue that helped us confirm its validity was the disappearance of emotional stress and the resolution of symptoms, when combined with Stratonikeia.Based on these findings, we conclude that ‘Antiochus I Soter suffered from ‘broken heart syndrome’. Bil To the best of our knowledge, the diagnosis of this historic case should be presented as a possible TCM. Antiochus was very lucky; He was unconditionally diagnosed and treated by Erasistratus, the first cardiologist described in history.

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